Is arterial stiffness a consequence of respiratory failure?
Research type
Research Study
Full title
The relationship between arterial stiffness and respiratory failure: using Motor Neurone Disease as a paradigm to assess the consequence of sleep disordered breathing on arterial stiffness
IRAS ID
210214
Contact name
Patrick Murphy
Contact email
Sponsor organisation
Guys and St Thomas’ Foundation Trust
Duration of Study in the UK
0 years, 6 months, 2 days
Research summary
In Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnoea (OSA) there are abnormalities in arterial stiffness due to hypoxemia with or without hypercapnia. These abnormalities in arterial stiffness could be driven by the risk factors for those conditions (e.g. cigarette smoke, obesity). Neuromuscular disease also causes hypoxemia and/or hypercapnia, without these risk factors. Thus the opportunity exists to determine whether hypoxemia and/or hypercapnia alone cause arterial stiffness. We hypothesized that arterial stiffness is increased in motor neurone disease patients with hypoxaemia including respiratory failure compared to those without and that non invasive ventilation has an effect on arterial stiffness in these patients. The study aims to compare the arterial stiffness in motor neuron disease patients with hypoxaemia and/or hypercapnia with those without. Patients will be treated according to the 'best clinical' practice and re-assessed after 6 week to assess for changes following treatment with non-invasive ventilation.
REC name
London - Chelsea Research Ethics Committee
REC reference
16/LO/1560
Date of REC Opinion
10 Nov 2016
REC opinion
Further Information Favourable Opinion