IPAC Study Database in Advanced Cancer : Retrospective CT analysis
Research type
Research Study
Full title
The relationship between body composition, tumour activity, functional activity and survival in patients with advanced cancer
IRAS ID
235523
Contact name
Barry Laird
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
The aim of the proposed study is to examine the relationship between the systemic inflammatory response body composition, tumour activity, functional activity and survival in patients with advanced cancer. This will be carried out by retrospectively interrogating data already collected as part of the IPAC study. This was a multicentre UK based study of over 300 patients examining the relationship between biomarkers and prognosis in patients with advanced cancer. Loss of lean muscle mass will be assessed using CT scans and image analysis. Tumour activity will be used by assessing PET-CT scans for the universally accepted markers of tumour activity maximum standard uptake (SUVmax), peak standardised uptake (SUVpeak), metabolic tumour volume (MTV) and total lesion glycolysis (TLG). Functional activity has been assessed using the 2min walk test/timed get up test, inflammation with mGPS/NLR and muscle quality with plain CT scans.
REC name
West of Scotland REC 4
REC reference
18/WS/0001
Date of REC Opinion
18 Jan 2018
REC opinion
Favourable Opinion