Investigations of RVD1 pathway in patients with emergency laparotomy
Research type
Research Study
Full title
Investigations of the association between ResolvinD1 and clinical outcomes in patients with sepsis requiring emergency laparatomy
IRAS ID
196005
Contact name
Fang Gao Smith
Contact email
Sponsor organisation
Heart of England NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
This study aims to investigate whether the absence and dysregulated function of a natural protein called ResolvinD1 (RvD1) can affect the clinical outcomes and mortality of patients undergoing an emergency laparotomy who acquire sepsis.
An emergency laparotomy is a surgical operation used to investigate the cause of severe abdominal pain by cutting open the abdomen. A high incidence of patients who have emergency laparotomy surgery develop severe abdominal sepsis with poor clinical outcomes. Thus, this can provide an excellent sepsis model to investigate in this study.Sepsis is defined as a systemic uncontrolled inflammatory response with a failure to resolve the inflammation when an infection occurs. Previous studies have found that RvD1, a natural protein in the immune system may influence how well a patient recovers from sepsis. RvD1 helps to regulate inflammation in the body by preventing excessive inflammation. If patients are found to have low levels of RvD1 this can lead to unresolved inflammation which can have detrimental effects on patient outcomes. However, there is deficient evidence to explain the relationship between RvD1, sepsis and clinical outcomes on patients undergoing emergency laparotomies. Therefore, this study will provide further investigation into this to help identify potential treatments to help improve patient outcomes.
This study will recruit patients undergoing emergency laparotomy who acquire sepsis from Birmingham Heartlands Hospital ( BHH) and University Hospital Birmingham
( UHB). A healthy volunteer group will be recruited from University Hospital Birmingham only.
Patients undergoing surgery will be allocated to the study group to compare against the healthy volunteers control group to investigate recovery and mortality rates up to 14 days after surgery. Blood samples will be collected from the patients for processing and analysis to investigate the underlying mechanism of RvD1 on the body and clinical outcomes.REC name
South Central - Oxford C Research Ethics Committee
REC reference
17/SC/0049
Date of REC Opinion
4 Aug 2017
REC opinion
Further Information Favourable Opinion