Investigation of traditional and nanoformulated medicines in humanised
Research type
Research Study
Full title
Investigation of traditional and nanoformulated medicines in humanised mice
IRAS ID
256042
Contact name
Andrew Owen
Contact email
Sponsor organisation
University of Liverpool
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
We aim to improve the effectiveness of human medicines by developing better ways of delivering the drugs to the sites in the body where they are needed to work. As part of our on-going work we are aiming to improve the predictive quality of our data to enable translation to human patients. Species differences make interpretation of data generated in preclinical animal models difficult to extrapolate to humans. Humanised rodents represent an opportunity to bridge the gap between preclinical species and humans. For example, humanisation of the immune system allows us to investigate how nanoformulations interact with the human immune system, allowing better prediction of the potential pharmacokinetic and safety implications. Additionally, a humanised immune system allows infection with human specific pathogens, allowing not only the investigation of distribution, but also efficacy of novel nanoformulations.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
19/NE/0048
Date of REC Opinion
8 Feb 2019
REC opinion
Favourable Opinion