Investigation of the MACE for early detection of dementia in over 75s
Research type
Research Study
Full title
An Investigation of the Utility of the Mini-Addenbrooke's Cognitive Examination (M-ACE) for the Early Detection of Dementia and Mild Cognitive Impairment in People Aged 75 and over.
IRAS ID
183123
Contact name
Jonathan Evans
Contact email
Duration of Study in the UK
0 years, 8 months, 1 days
Research summary
The aim of this study is to investigate the clinical utility of the Mini-Addenbrooke's Cognitive Examination (M-ACE) for detecting dementia and mild cognitive impairment in people aged 75 and over. There are a range of screening tools available to clinicians however shorter cognitive tools are particularly useful in busy clinical settings. The Mini Mental State Examination (MMSE; Folstein et al, 1975) is one of the most widely used screens. Despite being recommended by national guidelines, namely the Scottish Intercollegiate Guidelines Network (SIGN) and National Institute for Clinical Excellence (NICE), the MMSE has several shortcomings. In 2014, Hsieh et al introduced the M-ACE, a shortened version of the widely used Addenbrooke's Cognitive Examination III - ACE III), a possible alternative to the MMSE. The current study aims to further the validation of the M-ACE by exploring its use in a UK clinical setting with individuals aged 75 and over. The study also aims to investigate whether the cut-off scores recommended by Hsieh et al (2014) in the original validation for the M-ACE are optimal. The study will involve administering the M-ACE to approximately 66 individuals aged 75 and over. 44 will be patients referred to a local Community Mental Health Team for investigation of memory problems, the remaining 22 will be healthy controls.
REC name
West of Scotland REC 3
REC reference
15/WS/0279
Date of REC Opinion
10 Dec 2015
REC opinion
Further Information Favourable Opinion