Investigation of drug allergy
Research type
Research Study
Full title
Development of molecular diagnostics for type IV hypersensitivity to medications.
IRAS ID
237075
Contact name
Michael R Ardern-Jones
Contact email
Sponsor organisation
University Hospital Southampton NHS Trust
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
The primary objective of this research is to develop tests to identify and or confirm which caused a drug hypersensitivity reaction after the event. Although we have already developed and regularly use cytokine production for diagnostic tests, this is expensive and complex. therefore we aim to develop assays based upon measurement of gene transcription instead. The primary reason for this is that a PCR based approach is more amenable to use in routine NHS diagnostic laboratories.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
17/NE/0346
Date of REC Opinion
7 Nov 2017
REC opinion
Favourable Opinion