Investigating Zika Targeting of Glioma Stem Cells
Research type
Research Study
Full title
Investigating Selective Infection of Glioma Stem Cells by Zika Virus
IRAS ID
238683
Contact name
Stephen Kelleher
Contact email
Sponsor organisation
University of Cambridge and Cambridge University Hospitals NHS Foundation Trust
Duration of Study in the UK
4 years, 4 months, 31 days
Research summary
We seek permission to analyse surplus specimens resected at craniotomy. We will first separate the tumour into single cells before infecting these specimens with Zika virus tagged with a marker so we can see which cells are infected by it. Following this we will use techniques to characterise the target cell for the virus. We also plan to infect tumour slices for staining.
No additional tissue will be removed from the patient and only tissue surplus to the needs for pathological analysis will be used. Fragments of tissue will
include:
a) Normal brain tissue resected by necessity in the course of the approach to the lesion
b) Lesion margins
c) Lesion bulk
These tissue types may be obtained directly from the surgical field, or indirectly by collecting the waste products from the ultrasonic tissue ablation apparatus used at operation.REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
18/WM/0094
Date of REC Opinion
18 Apr 2018
REC opinion
Further Information Favourable Opinion