Investigating the Role of Salt Inducible Kinases in Atherosclerosis v1
Research type
Research Study
Full title
Investigating the Role of Salt Inducible Kinases in Atherosclerosis
IRAS ID
195108
Contact name
Faisel Khan
Contact email
Duration of Study in the UK
1 years, 6 months, 2 days
Research summary
Cardiovascular disease is most commonly experienced as heart attacks (MI) and strokes, however the early stages of it are characterised by changes in the function of the blood vessels, particularly the arteries. Some of these changes in function of the arteries are caused by inflammation, and in theory reducing inflammation could potentially reduce the risk of MI and stroke. In animal studies we have found that certain substances (called SIKs) promote inflammation in the arteries. We now wish to see if this is the case in humans, and so we plan to conduct tests in both healthy controls and patients with established cardiovascular disease (MIs and narrowing of the leg arteries). We also wish to compare these levels with non-invasive measures of artery function. If SIK levels are found to be high then this might be a potential new treatment target to prevent cardiovascular disease.
REC name
East of Scotland Research Ethics Service REC 1
REC reference
16/ES/0068
Date of REC Opinion
23 Jun 2016
REC opinion
Further Information Favourable Opinion