Investigating the gut microbiome and symptomology in IBS

• Research type

  Research Study

• Full title

  Investigating the gut microbiome and symptomology in IBS: Mechanisms and therapeutic implications for symptom relief through prescribed physical activity in clinical practice.

• IRAS ID

  345554

• Contact name

  Hannah Lindsell

• Contact email

  hannah.lindsell@ntu.ac.uk

• Sponsor organisation

  Nottingham Trent Univeristy

• Clinicaltrials.gov Identifier

  NCT06708533

• Duration of Study in the UK

  2 years, 0 months, 0 days

• Research summary

  This will be a baseline and optional 12-week physical activity intervention study, in patients with clinically diagnosed irritable bowel syndrome (IBS). This project aims to explore whether the function and composition of the gut microbiome, IBS symptomology, and other physiological biomarkers vary across different IBS-subtypes (IBS-Constipation, IBS-Diarrhoea, IBS-Mixed) and healthy controls. Additionally, we will investigate whether a 12-week physical activity intervention could be an effective therapeutic management strategy for IBS patients, to reduce symptomology, and improve quality of life.

  This study will explore whether physical activity relieves IBS symptoms (measured through various validated questionnaires) and physiological measures (blood, urine and faecal samples).

• REC name

  London - Camberwell St Giles Research Ethics Committee

• REC reference

  24/PR/1549

• Date of REC Opinion

  26 Mar 2025

• REC opinion

  Further Information Favourable Opinion