Investigating the communication between myeloid cells and cancer cells
Research type
Research Study
Full title
Investigating the communication between myeloid cells and cancer cells, to probe the impact on tumour growth, metastasis and immune evasion
IRAS ID
269363
Contact name
Victoria Sanz-Moreno
Contact email
Sponsor organisation
Joint Research Management Office (JRMO)
Duration of Study in the UK
3 years, 4 months, 20 days
Research summary
The material will be used as part of a reseach project aimed at understanding the mechanisms of immune responses to cancer progression. The material will only be used for this study and will not be shared with any other organizations. The project involves peripheral blood mononuclear cell isolation from blood samples from anonymised health donors. This is followed by several types of immune cell isolation, such as monocytes or lymphocytes. The activation status and phenotype of immune cells will be checked after culturing them in the presence of media derived from melanoma cell lines or co-culture systems with other immune cells or melanoma cells. Therefore, staining for phenotypic markers and flow cytometry will be performed. This peripheral blood mononuclear isolation and polarisation procedure will also be used for transcriptomic analysis to look at global gene expression changes, and use in animal models to look at tumour growth and metastasis.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
19/LO/1804
Date of REC Opinion
25 Nov 2019
REC opinion
Favourable Opinion