Investigating risk factors for development of Gynaecological Cancer
Research type
Research Study
Full title
Development of a Gynaecological Cancer risk-prediction model: A prospective study.
IRAS ID
335523
Contact name
R Pounds
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
The study aims to identify the underlying genetic alterations that may lead to the development of gynaecological cancers and influence recurrence of disease. This longitudinal clinical study will recruit patients with gynaecological cancer, alongside patients with pre-malignant and benign conditions as well as healthy volunteers. By analysing tissue and blood samples, the study aims to detect genetic mutations and changes in the primary tumour, metastatic tumour deposits, recurrent tumours and also in pre-malignant and normal tissues. The study will identify tumour markers that can be utilised to detect the development of early cancers and predict tumour recurrence. This will allow clinicians to initiate treatment in a timely manner, before tumours have progressed to advanced stage and metastatic disease. Understanding the genetic alterations will enable us to develop a predictive molecular algorithm to quantify and predict the risks of gynaecological cancer progression and recurrence
REC name
London - London Bridge Research Ethics Committee
REC reference
24/PR/0797
Date of REC Opinion
8 Aug 2024
REC opinion
Further Information Favourable Opinion