Investigating Epstein-Barr Virus Associated Conjunctivitis
Research type
Research Study
Full title
Investigating Epstein-Barr Virus Associated Conjunctivitis
IRAS ID
342525
Contact name
Frank Larkin
Contact email
Sponsor organisation
Moorfields Eye hospital NHS foundation trust
Duration of Study in the UK
0 years, 8 months, 2 days
Research summary
Conjunctivitis means inflammation of the conjunctiva, the thin transparent layer over the white of the eye and under the eyelids. Acute conjunctivitis caused by infection is the most common condition seen in ophthalmic emergency departments, accounting for up to 10% of cases. It is responsible for 41% of eye-related general practice consultations. A diagnosis is usually made on the patient's symptoms and signs, despite this being less reliable than laboratory testing. When a cause is found, it is usually a common cold virus called adenovirus, that gets better with time and does not require treatment.
Through investigating cases of conjunctivitis at Moorfields, we have discovered that in addition to adenovirus, Epstein-Barr virus (EBV) is sometimes detected in conjunctival swabs from individuals with conjunctivitis. EBV is a very common viral infection that 95% of adults have experienced. EBV infection mostly passes unnoticed but when symptoms do occur, they include a sore throat, high temperature, swollen glands and tiredness, often called glandular fever or infectious mononucleosis. Conjunctivitis can also occur. EBV remains in your body after infection and rarely causes further problems. The virus can become active again occasionally, which is known as reactivation. Reactivation usually passes unnoticed but sometimes is associated with recurrence of symptoms. It is possible that reactivation may cause conjunctivitis. We are not certain, which is why we are studying it, as it might be the cause of some of the conjunctivitis we see.
Through a collaboration with University College London (UCL), we hope to gain further insight into infectious conjunctivitis, particularly in relation to EBV. This will be done by taking a swab of the conjunctiva, a single blood test and a tiny (1-2mm) tissue sample from the inner eyelid. Improved knowledge will allow us to develop better guidance and treatment for patients with conjunctivitis.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
24/YH/0160
Date of REC Opinion
16 Aug 2024
REC opinion
Favourable Opinion