Investigating dietary intake in women with recurrent miscarriage
Research type
Research Study
Full title
A Study Investigating Dietary Intake in Women with Recurrent Miscarriage to Determine if there is a Relationship between Nutrition Intake, Placental Cells and Pregnancy Outcomes.
IRAS ID
335431
Contact name
Fatima Koroma
Contact email
Sponsor organisation
Edge Hill University
Clinicaltrials.gov Identifier
n/a, n/a
Duration of Study in the UK
2 years, 6 months, 5 days
Research summary
We are interested in studying the food intake of women ahead of and during the early stages of pregnancy who have experienced 3 or more miscarriages. We would also like to explore whether there is a relationship between food intake (specifically certain micronutrients such as vitamin D) and miscarriage. As well as the effect this has on pregnancy outcomes such as pre-term birth and small for gestational age infants. We would also like to investigate whether levels of certain micronutrients have an impact on genes and the effect this has on expression of such genes. At present there is limited research in this area, and the causes for miscarriage are often due to various factors which may be beyond our control. Understanding whether there is relationship between dietary intake, miscarriage, gene expression and pregnancy outcomes is important. This will develop an understanding of these factors and add to this area of research, which will hopefully inform and influence future research and policymakers.
The study will recruit women who have experienced 3 or more miscarriages and have been referred to the Recurrent Miscarriage Clinic (RMC) at the Liverpool Women’s Hospital. The aim of the study is to explore the dietary intake of:
-preconceptual women (women attend the RMC with the aim of conceiving in the near future).
-and women in their 1st trimester (0-14 weeks) of pregnancy.
Women participating in phase 1 of the study will be asked to complete 3-day food diary to record their food intake and have a blood sample taken (from the vein).The researcher will request (with permission) personal health records (gynaecologist reports and obstetric records). Women who complete phase 1 of the study will be asked to take part in phase 2 of the study, which will involve partaking in a one-to-one interview at >20 weeks of pregnancy.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
24/NW/0165
Date of REC Opinion
27 Jun 2024
REC opinion
Further Information Favourable Opinion