Investigating a role for IGFII in adipocyte regulation

• Research type

  Research Study

• Full title

  Investigating a role for IGFII in adipocyte regulation: differential effects on visceral adipocytes via insulin receptor isoforms.

• IRAS ID

  152062

• Contact name

  J.P. Hamilton-Shield

• Contact email

  Julian.Shield@bristol.ac.uk

• Sponsor organisation

  Research and Enterprise Development, University of Bristol

• Research summary

  Investigating a role for Insulin Growth Factor (IGFII) in Adipocyte regulation.
  Background: humans have evolved for an active lifestyle with much more intermittent feeding. The adipocyte has a critical role, normally functioning to buffer changes in availability of metabolic fuels, storing lipids at times of plenty and then providing a source of energy during times when food is limited. The distribution of body fat has greater importance for the development of obesity related morbidities than the simple extent of excess adipose tissue. Although the vast majority of fat is held in subcutaneous adipose tissue, visceral adiposity is more closely associated with the development of metabolic syndrome, type 11 diabetes mellitus and cardiovascular disease. It has also become apparent the adipocytes from different anatomical sites serve distinct functional roles. AIM: We suggest that differential distribution of insulin receptor isoforms between visceral and subcutaneous adipocytes may enable IGFF11 to have specific effects on visceral fat depots. Method: We will create a collection of pre adipocytes from biopsies of normal children undergoing routine surgery for non malignant non specific conditions. These cells can then be grown and differentiated into mature adipocytes . using bio cellular specific models we want to investigate the differences in the distribution of insulin reptor isoforms between visceral and subcutaneous adipocytes and its possible metabolic consequences.

• REC name

  South West - Cornwall & Plymouth Research Ethics Committee

• REC reference

  14/SW/0109

• Date of REC Opinion

  4 Jul 2014

• REC opinion

  Further Information Favourable Opinion