INVEST CTO
Research type
Research Study
Full title
Invest-CTO: Effectiveness and Safety of a Planned Investment Procedure in High-Risk CTO PCI
IRAS ID
295564
Contact name
Margaret B McEntegart
Contact email
Sponsor organisation
Haukeland University Hospital
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Anginal chest pain is caused by narrowing or blockages in the blood supply to the heart (coronary arteries). A chronic total occlusion (CTO) is a blockage in a coronary artery that has been present for at least three months. Only 1 in 10 patients with a CTO get this treated by stents, mainly because the procedures are difficult and often associated with complications.
When treating more complex blockages, procedure success rates are ~70%, with complication rates 5-10%, and 1 in 3 patients need to return for a second procedure to complete treatment. It appears that if the artery is partially unblocked during a first procedure, it is easier and less risky to complete the unblocking and stent implantation with a second procedure.
We are investigating whether planning to treat the blockage across 2 procedures may result in higher success and lower complication rates.REC name
West of Scotland REC 5
REC reference
22/WS/0006
Date of REC Opinion
16 Feb 2022
REC opinion
Further Information Favourable Opinion