INVEST
Research type
Research Study
Full title
Novel pleural fluid, biopsy and serum biomarkers for the investigation of pleural effusions / INVEST
IRAS ID
211126
Contact name
Najib Rahman
Contact email
Sponsor organisation
University of Oxford
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
Research Summary:
A prospective observation study examining the clinical utility of novel pleural fluid, biopsy and serum biomarkers for the investigation of pleural effusions (INVEST). The INVEST study will collect blood, pleural fluid and tissue samples from donors, allowing the opportunity to apply several novel blood and pleural fluid tests with interpretation of results in the context of clinical data and diagnostic suspicion. Through the prospective application of multiple tests, we aim to validate the sensitivity and specificity of existing biomarkers and identify novel markers that aid in the diagnostic pathway of pleural diseases. Because samples and data will be stored for future use, many other different tests, methods and techniques may be used in the future to provide information that we cannot foresee.Summary of Results:
The purpose of this study was to prospectively assess established biomarkers in the diagnosis and prognosis of patients. Our preliminary data show that the established biomarkers could differentiate between the different types of pleural effusions.REC name
South Central - Oxford B Research Ethics Committee
REC reference
17/SC/0333
Date of REC Opinion
19 Jul 2017
REC opinion
Favourable Opinion