Inulin Propionate Ester and Post-exercise Energy Compensation
Research type
Research Study
Full title
The Impact of Targeted Colonic Propionate Delivery in Humans on Post-Exercise Energy Compensation
IRAS ID
272449
Contact name
Gary Frost
Contact email
Sponsor organisation
Imperial College London
Clinicaltrials.gov Identifier
-, -
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
To tackle the problem of obesity, amongst the most valuable tools are exercise for weight management and temporary hunger sensation, and increased consumption of dietary fibre for decreased appetite. The effect of acute oral supplementation of an inulin-propionate ester (IPE) has been highlighted involving the subsequent release of short chain fatty acids
like propionate/PYY/GLP-1 in the colon and the decrease of energy intake. This novel dietary
strategy acts as the first proof that elevated colonic propionate can cause short-term satiet,
and improve long-term weight gain; however, the exact mechanism is yet to be determined.
In this project we include a randomized, placebo-controlled, double-blind, cross-over
study. We will determine the short-term effects of IPE on post-exercise
compensatory eating and appetite response in overweight and obese population. Following
healthy screening and baseline measurements, participants will consume 10g of either IPE or cellulose (control) in a drink followed by a 45-min of low-to-moderate intensity exercise.
During 4 visits, we will perform various measurements including gut hormones and
metabolites in blood, appetite and gastrointestinal disturbances, blood pressure, heart rate, energy expenditure and appetite response via an ad libitum pasta meal at the end of the study.REC name
London - Brent Research Ethics Committee
REC reference
20/LO/0658
Date of REC Opinion
25 Jun 2020
REC opinion
Further Information Favourable Opinion