Intravenous iron replenishment and mood in surgical patients
Research type
Research Study
Full title
Investigating the effect of intravenous iron correction, in iron-deficient anaemic patients awaiting planned surgery, on depression and anxiety levels
IRAS ID
290558
Contact name
Daniel Wirth
Contact email
Sponsor organisation
Homerton University Hospital, R+D Team
Duration of Study in the UK
0 years, 6 months, 2 days
Research summary
Pre-operative iron-deficiency anaemia is an important risk factor that needs correcting in the planned surgical patient. This can be diagnosed with low ferritin or iron saturation levels, in the context of anaemia. This can be corrected with intravenous iron therapy. A few weeks after the infusion, repeat blood tests are undertaken to confirm correction of the iron deficiency and anaemia. After this, surgery can go ahead. This is part of our standard protocol at Homerton Hospital, for certain planned surgeries.
We hypothesise that low iron levels and anaemia contribute to depression and anxiety, and following intravenous correction, the depression and anxiety levels may improve.
We plan to undertake a questionnaire study. The patients will be recruited to undertake a pre-infusion depression survey and an anxiety survey. Following correction of iron deficiency, a few weeks later, the same surveys will be carried out.
We will compare pre and post survey responses.
REC name
London - London Bridge Research Ethics Committee
REC reference
20/PR/0744
Date of REC Opinion
21 Dec 2020
REC opinion
Further Information Favourable Opinion