Intraoperative Laparoscopic NIR ICG Anastomotic Perfusion Assessment
Research type
Research Study
Full title
Anastomotic Perfusion assessment with IndoCyanine green fluorescence & near infra-red Angiography in Laparoscopic anterior resections (’APICAL’ Study)
IRAS ID
139399
Contact name
Omar Faiz
Contact email
Sponsor organisation
Northwest London Hospitals NHS Trust
Research summary
This study aims to assess the feasibility of using Indocyanine Green (ICG) dye fluorescence to qualitatively assess perfusion around the anastomotic site or ’joint’ between bowel ends, during colorectal surgery. The autofluorescence capabilities of ICG under near infra-red light (NIR) is being utilized in this instance.
Currently, the assessment of the anastomotic site is being done intraoperatively using clinical factors and surgical factors which are observed through tactile touch and viewed under normal ’white light’ by the operating surgeon.
NIR-ICG imaging modality will allow the surgeon to assess the perfusion of the site ’visually’ by fluorescing in areas where there is blood flow and perfusion. Furthermore, this will allow the surgeon to have ’real-time’ information on anastomotic perfusion, on which he/she can act on intraoperatively and potentially prevent postoperative complications and reoperations.
This feasibility study will include 20 patients with left sided colorectal malignancies amenable to laparoscopic curative resection, who are anticipated to have an anastomosis which is within 15 centimetres from the anal verge. They will be selected consecutively from our unit’s multi-disciplinary team meetings.
This feasibility study will be conducted in St Mark’s Hospital and is expected to be accrue patients in 9 to 12 months.
REC name
London - Fulham Research Ethics Committee
REC reference
13/LO/1573
Date of REC Opinion
26 Nov 2013
REC opinion
Further Information Favourable Opinion