Intraoperative Gadolinium (IG)
Research type
Research Study
Full title
A prospective observational study of Intraoperative Gadolinium administration for analysis of human aneurysm walls
IRAS ID
293787
Contact name
Diedeirk Bulters
Contact email
Sponsor organisation
University Hospital Southampton
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Intracranial aneurysm has a prevalence in the population of up to 3%, however the incidence of Sub-Arachnoid haemorrhage (haemorrhagic stroke) is 0.007%. As these bleeds can be devastating, it makes deciding which aneurysms needing treatment a difficult decision as most will not go to rupture. Recently MRI techniques such as Dynamic contrast enhancement and vessel wall imaging, have been shown to be able to predict aneurysm growth and by proxy their rupture. However, the reason why the aneurysms enhance on imaging is not understood, this information can be useful for understanding not only why some aneurysms are unstable but potentially why they arise. This study proposes to examine the aneurysm wall of human specimens that have been excised intraoperatively, and to determine what the positive enhancement on MRI is pathologically referring to in the wall. To achieve this we will give a dose of gadolinium contrast intraoperatively before excision, so that we can use it as marker for spatial mass spectrometry analysis and localise the gadolinium in the wall to determine what layer of the wall is making theses aneurysms enhance. This information could shed light on what makes aneurysms more unstable, leading to insights on their formation.
REC name
South Central - Hampshire A Research Ethics Committee
REC reference
22/SC/0174
Date of REC Opinion
4 Aug 2022
REC opinion
Further Information Favourable Opinion