Intracellular magnesium and Heart Failure
Research type
Research Study
Full title
Exploring Intramyocellular Magnesium Augmentation: Implications for Myocardial and Skeletal Muscle Metabolism in Individuals with Heart Failure with Preserved Ejection Fraction
IRAS ID
331039
Contact name
Oliver Rider
Contact email
Sponsor organisation
University of Oxford / Research Governance, Ethics and Assurance
Duration of Study in the UK
2 years, 3 months, 24 days
Research summary
In patients with heart failure, serum hypomagnesaemia is common and attributed to increased renal magnesium (Mg2+) secretion and diuretic therapy. Serum hypomagnesemia is associated with increased heart failure presentations and hospitalisations in patients with heart failure with preserved ejection fraction (HFpEF). There is a poor correlation between serum Mg2+ (the compartment which can be measured) and intracellular Mg2+ concentrations9 (the compartment in which Mg2+ regulates cellular processes) with serum Mg2+ being a poor surrogate for total body Mg2+ content. Using 31 phosphate magnetic resonance spectroscopy (31P-MRS), intracellular Mg2+ can be assessed in vivo, without the need for a biopsy. This study is a single-centre, cohort comparison study. It aims to assess the relationship between intracellular Mg2+, and cardiac and skeletal muscle energetics and function. It also investigates the effect of increasing magnesium as a potential therapeutic target in HFpEF. Participants are separated into three groups; participants with HFpEF (n=45), age and BMI matched controls (n=20) and healthy controls (n=20). The study comprises two visits, where individuals will undergo a variety of investigations pre and post intravenous magnesium infusion. These include blood tests such as serum Mg2+ and NT pro-BNP, a calf raise test, cardiac magnetic resonance imaging (MRI) and spectroscopy (MRS), skeletal muscle MRS, and echocardiogram. Imaging and spectroscopy measurements are performed twice; at rest and stress (either with exercise or dobutamine). Study visit one will analyse the affects of magnesium pre and immediately post supplementation, and study visit two will repeat investigations 7-15 days after Mg2+ infusion to assess for delayed changes.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
24/PR/0026
Date of REC Opinion
25 Mar 2024
REC opinion
Further Information Favourable Opinion