Intentional non-adherence to treatment in skin conditions
Research type
Research Study
Full title
What correlates with intentional non-adherence to treatment in Chronic Spontaneous Urticaria and Eczema?
IRAS ID
247404
Contact name
John Weinman
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
0 years, 2 months, 20 days
Research summary
Non-adherence to treatment refers to patients not taking their prescribed treatment as agreed with their clinician. There are two main types of non-adherence, unintentional non-adherence which occurs for reasons such as forgetfulness which are beyond the individuals' control, and intentional non-adherence which occurs when the patient actively decides not to follow treatment recommendations.
The reasons for intentional non-adherence across chronic conditions are not well understood and interventions to improve adherence rates have been sub-optimal and therefore more research into this area is needed. A newly developed scale that is currently under review for publication named the INAS (Intentional Non-adherence Scale), will be used in this study, aims to identify the main reasons why individuals are intentionally non-adherent to their prescribed treatments.
Non-adherence is a major problem in patients with the following two skin conditions 1)chronic spontaneous urticaria and 2)eczema. Previous research has shown that these patients commonly suffer from poor quality of life, distress and increased symptom reporting as a result of non-adherence.
The INAS (Intentional Non-adherence Scale) will be used to assess the main reasons for intentional non-adherence in chronic spontaneous urticaria and eczema patients and will attempt to reveal more about the variance in patient adherent behaviour.
The study will also examine whether the items on the Intentional Non Adherence Scale (INAS) correlate with existing validated measures which will also be given to the patients at Guy's & St Thomas' hospital when they attend their appointment in the dermatology clinic.
Questionnaires given to eczema patients are: brief-IPQ, MARS-5, BMQ, DLQI, BODE, EASI. For urticaria: brief-IPQ, MARS-5, BMQ, DLQI, CUPP, and Patient Global Assessment. Both the Physician Global Assessment and EASI will form part of the clinician’s assessment for the respective conditions.
The battery should take no longer than 15 minutes to introduce and complete but participants will be allocated 30 minutes.
REC name
London - Queen Square Research Ethics Committee
REC reference
18/LO/1412
Date of REC Opinion
3 Aug 2018
REC opinion
Favourable Opinion