Integrating PRS and transcriptomics for coronary heart disease

• Research type

  Research Study

• Full title

  Integrating polygenic risk score and transcriptomic profiling for coronary heart disease prevention

• IRAS ID

  312629

• Contact name

  Stavroula Kanoni

• Contact email

  s.kanoni@qmul.ac.uk

• Sponsor organisation

  Barts Health NHS Trust & Queen Mary University of London

• Duration of Study in the UK

  1 years, 0 months, 31 days

• Research summary

  We want to identify a subset of British South Asian individuals at low, intermediate and high genetic risk for coronary heart disease (CHD) to investigate how their transcriptomic profile could advance the overall prediction for CHD through advanced machine learning and AI algorithms. Our aim is to develop an innovative diagnostic method to further the personalised diagnostic ability for CVD risk ensuring its performance in South-Asians. We intend to recall individuals that are already participants of the Genes and Health Study.

• REC name

  North West - Greater Manchester South Research Ethics Committee

• REC reference

  22/NW/0179

• Date of REC Opinion

  14 Jun 2022

• REC opinion

  Further Information Favourable Opinion