Integrated Flow Reserve in the Heart and End-organs of ACHD patients
Research type
Research Study
Full title
Integrated Circulatory Flow Reserve in the Heart and Body Organs in Congenital Heart Disease: a precision medicine-based approach to more accurate assessment of health status, morbidity, outcomes, and prognosis.
IRAS ID
300056
Contact name
Gruschen Veldtman
Contact email
Sponsor organisation
Golden Jubilee Hospital
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
The heterogeneity of congenital heart disease anatomy, pathophysiology, and surgical sequelae has created complex clinical situations which do not lend itself to empiric and iterative treatment approaches. This has created an urgent need for a more personalized approached to diagnostics, surveillance, and treatment, to better develop service delivery, and improved risk stratification.
Currently, the clinical assessment of adult patients with congenital heart disease [CHD] in dependent on physician physical assessment, rest echocardiography and in selected cases cardiopulmonary exercise testing and in even fewer cases exercise echocardiography. An integrated approach to exercise echocardiography in combination with stress end-organ flow reserve in the lungs, liver, kidney, and splanchnic circulations offer the potential for a more patient specific and wholistic cardiovascular assessment that is expected to better predict true clinical status, prognosis, likely outcome during intervention and likelihood for the development of significant clinical morbidity. Further, such personalized approaches to individual physiological reserve, may also permit greater evidence-based rationalization of clinical resources.REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
21/NE/0142
Date of REC Opinion
3 Nov 2021
REC opinion
Further Information Favourable Opinion