INGR1D2
Research type
Research Study
Full title
Identification of infants with increased type 1 diabetes risk for enrolment into primary prevention trials
IRAS ID
298196
Contact name
Stephen Robson
Contact email
Sponsor organisation
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Primary prevention of common chronic disease is a major public health goal. Type 1 diabetes is a common chronic disease in childhood and is increasing in incidence. The clinical onset of type 1 diabetes is preceded by a phase where the child is well but has multiple beta-cell auto-antibodies in their blood against insulin-producing beta cells,which are present in the pancreas. Neonates and infants who are at increased risk of developing multiple beta-cell auto-antibodies and type 1 diabetes can now be identified using genetic markers. This provides an opportunity for introducing early therapies to prevent beta-cell autoimmunity and type 1 diabetes.
The objective of this study is to determine the percentage of children with genetic markers putting them at increased risk of developing type 1 diabetes, and to offer the opportunity for these children to be enrolled into phase II b primary prevention trials.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
21/NE/0161
Date of REC Opinion
14 Oct 2021
REC opinion
Further Information Favourable Opinion