Inflammatory response & dietary habits in bowel screening participants

• Research type

  Research Study

• Full title

  Investigation of the local and systemic inflammatory response and of dietary habits in those attending for investigation via the Scottish Bowel Screening Programme

• IRAS ID

  150111

• Contact name

  Campbell Roxburgh

• Sponsor organisation

  NHS Greater Glasgow and Clyde

• Duration of Study in the UK

  1 years, 0 months, 0 days

• Research summary

  Colorectal cancer (CRC) is the 2nd most common cause of cancer-related death in the UK (2010) accounting for around 10% of all cancer deaths. In the UK, 41,000 new cases are diagnosed per year with 16,000 deaths. The Scottish Bowel Screening Programme was introduced across Scotland in a phased manner beginning in 2007. There is good evidence that screening for colorectal cancer increases the number of early-stage cancers diagnosed and the number of precancerous adenomas removed and as a result leads to a reduction of cancer specific mortality.
  Dietary compounds such as polyphenols have recently attracted attention as potential agents in the treatment of early stage colorectal cancer since they have low toxicity compared with current drugs.
  Inflammation has recently been recognised as the seventh hallmark of cancer and current evidence suggests a role for inflammation in the pathogenesis of CRC.There is a body of evidence to support the concept that infiltration of immune cells in the locality of the tumour is associated with improved clinical outcome in colorectal cancer, whilst the presence of a systemic inflammatory response has been established as a predictor of recurrence and of overall survival. Calprotectin is a neutrophil derived protein which can be quantified in the faeces and is accepted as a marked of gut inflammation.It has been found in increased concentrations in those with colorectal cancer, inflammatory bowel disease and other inflammatory disorders.

  This study aims to investigate the impact of dietary components on the colonic health of people who present via the Scottish Bowel Screening Programme by administration of a food frequency questionnaire and to ascertain the effect of the inflammatory response by measurement of faecal calprotectin and serum CRP, differential WCC and albumin. We also wish to access local inflammatory cell infiltrate in pathological specimens taken at screening colonoscopy.

• REC name

  Wales REC 6

• REC reference

  15/WA/0053

• Date of REC Opinion

  19 Feb 2015

• REC opinion

  Further Information Favourable Opinion