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Inflammatory Response and Organ Injury in Cardiac Surgery Patients

  • Research type

    Research Study

  • Full title

    Association between Systemic Inflammatory Response and Organ Injury in Cardiac Surgery Patients: An Individual Patient Data Meta-analysis

  • IRAS ID

    246897

  • Contact name

    Gavin J Murphy

  • Contact email

    gjm19@leicester.ac.uk

  • Sponsor organisation

    University of Leicester

  • Duration of Study in the UK

    2 years, 0 months, 1 days

  • Research summary

    The aim of the study is to investigate organ injury developed after cardiac surgery across patient groups, and how this may relate to post-operative inflammatory response.

    Organ injury and dysfunction of the kidney, heart and lungs after cardiac surgery are not uncommon and care of patients with organ injury has significant resource implication. Cardiopulmonary bypass (CPB) during the surgery is known to induce systemic inflammatory response and is an important cause of organ injury. However, interventions targeted at attenuating inflammation caused by CPB have not been shown to reduce organ injury in clinical trials.

    The mechanisms of how inflammation causes organ injury is not well understood. We hypothesise that systemic inflammatory response is not the key determinant of clinical outcomes in cardiac surgery, but the interaction between inflammatory response and patients' baseline clinical status that determines the outcomes. In this study, we will investigate the post-operative organ injury across patient groups and its relationship with inflammatory response. In particular, we will examine this relationship in young and old patients, normal weight and obese patients, as well as patients with and without underlying medical conditions including diabetes and chronic kidney disease.

  • REC name

    West of Scotland REC 3

  • REC reference

    18/WS/0148

  • Date of REC Opinion

    5 Sep 2018

  • REC opinion

    Further Information Favourable Opinion