Inflammatory, metabolic, endocrine, immunological pathways in arteries and veins
Research type
Research Study
Full title
Inflammatory, metabolic, endocrine and immunological pathways in arteries and veins used in heart bypass surgery.
IRAS ID
170899
Contact name
Mahmoud Loubani
Contact email
Sponsor organisation
Hull and East Yorkshire R and D department
Duration of Study in the UK
0 years, 5 months, 27 days
Research summary
Atherosclerosis is a potentially serious condition affecting your blood vessels. Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your body. In atherosclerosis arteries accumulate cholesterol, calcium, and other substances found in the blood. Inside many arteries there is fat called perivascular adipose tissue which is metabolically active can attract inflammatory, metabolic, immunological and endocrine molecules and can influence how well the artery can function. Some of these molecules (such as interleukin 7 and others) may cause inflammation to worsen, contribute to abnormal immune cell functioning (T and B cells) and perhaps make the plaque more prone to rupture which may result in a heart attack or stroke. Therefore a thorough understanding of the diverse inflammatory, metabolic, immunological and endocrine molecules produced by the arteries and veins is very important. When we know which molecules are raised in the arteries we can use this information to target these molecules which may prevent a worsening of atherosclerosis and a reduction in heart attacks.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
15/NE/0138
Date of REC Opinion
15 Apr 2015
REC opinion
Favourable Opinion