Inflammation on muscle protein synthesis and immune cell function v1
Research type
Research Study
Full title
To determine the effect of surgical induced systemic inflammation on immobilisation induced declines in muscle protein synthesis and immune cell function.
IRAS ID
267153
Contact name
Matthew Brook
Contact email
Sponsor organisation
The University of Nottingham
Clinicaltrials.gov Identifier
0000, 0000
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
After surgery, most patients are subject to bed rest in order to recover. During this time, we perform very little movement in what we would call immobilisation. Periods of immobilisation after surgery cause us to rapidly lose muscle mass and strength, making it more difficult to recover back to activities of daily living. However, during surgery, our body also produces a stress response called inflammation, that causes our muscles to shrink and also makes our immune systems weaker. Currently, we don’t know precisely how inflammation after surgery enhances the negative effects of immobilisation on our muscles and immune system, therefore we currenlty have no effective treatments. We will use a special type of water called 'heavy water' that will let us study how inflammation caused by routine surgery effects our muscles and immune system so that in the future we can develop treatments.
REC name
Wales REC 4
REC reference
20/WA/0238
Date of REC Opinion
2 Oct 2020
REC opinion
Further Information Favourable Opinion