Inflammation in intracerebral haemorrhage
Research type
Research Study
Full title
Inflammation after intracerebral haemorrhage: understanding the pathophysiology to enhance brain repair
IRAS ID
241340
Contact name
Anan Shtaya
Contact email
Sponsor organisation
St George's University of London
Clinicaltrials.gov Identifier
18/LO/1892, REC- LONDON-SOUTHEAST
Duration of Study in the UK
3 years, 8 months, 26 days
Research summary
Brain haemorrhage (ICH) represents 10-15% of all strokes and results from direct bleeding into the brain. Death and disability following ICH are common. Following ICH while there is direct injury to the brain by the expanding ICH, the surrounding brain is further injured by inflammation and swelling around the ICH that result in death of brain cells. While clinical trials have investigated the role of surgical removal of the ICH and/or dissolving it, the reaction and injury in the surrounding brain is much less studied and consequently there are no treatments to improve this.
In our study, we will investigate the inflammatory response in patients with ICH. We will study samples taken from patients undergoing surgical removal of ICH, blood and fluid around the brain.The results of this study will help us to understand how the human brain repairs itself and clears the blood mass. Identification of patients’ specific markers within the blood and brain tissue and fluids will guide future studies and therapeutic approaches to treat patients with brain haemorrhages.REC name
London - South East Research Ethics Committee
REC reference
18/LO/1892
Date of REC Opinion
7 Jan 2019
REC opinion
Further Information Favourable Opinion