iNAAN in the UK
Research type
Research Study
Full title
International Network of Antibiotic Allergy Nations in the United Kingdom
IRAS ID
333469
Contact name
Neil Powell
Contact email
Sponsor organisation
Royal Cornwall Hospital
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Fifteen percent of hospitalised patients have a self-reported penicillin allergy (penA) record which means these patients are not prescribed first line penicillin antibiotics, instead receiving second or third line antibiotics which are associated with poorer patient outcomes (e.g. treatment failure and increased mortality) and poorer healthcare outcomes (e.g. increased length of hospital stay and increased treatment costs). These poorer outcomes are unnecessary because more than 90% of patients with self-reported penicillin allergy records are not allergic to penicillin and can therefore to be prescribed first line penicillin. The literature supports the safety of hospital doctors and pharmacists removing penicillin allergy records and prescribing penicillin to patients with low risk penicillin allergy records. Participant hospitals will use their national guidelines on penA de-labelling to develop their own hospital guidelines that will enable penicillin allergy risk assessment and de-label as a standard of care for hospitalised patients delivered by either ward doctors, ward pharmacists ward nurses, or infection specialists (doctors or pharmacists) and operate within the hospital's local governance structures. Pen A de-labelling study will be delivered in UK hospitals with patient data collected on those who are risk assessed for penA testing (e.g. patient demographics, antibiotic prescribing and patient outcomes) from each UK site then anonymised and entered to the international REDcap data set for patients from the international collaborating sites in Australia, Canada, South African and the UAE. This anonymised data set will be interrogated to compare antibiotic prescribing outcomes and patient outcomes between those patients with penicillin allergy records that have their PenA record removed and those that do not have their penA removed to determine whether de-labelling reduces the harms associated with penicillin allergy labels.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
23/YH/0282
Date of REC Opinion
21 Dec 2023
REC opinion
Further Information Favourable Opinion