In-Lab Viability
Research type
Research Study
Full title
Evaluation of a novel physiological biomarker of hibernation in ischaemic left ventricular dysfunction
IRAS ID
220426
Contact name
Matthew Ryan
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Heart failure is a common condition that adversely affects the quality of life and longevity of sufferers. The most common cause is narrowing of the heart arteries, which leads to irreversible scarring of the heart muscle or causes the heart muscle to enter a state called hibernation, where it remains alive but inactive. Treatment of heart arteries can restore function if the muscle is hibernating but not if it is scarred and so, distinguishing these states is the key to selecting patients who will benefit. Currently available tests, including nuclear and MRI scans, have limited accuracy at predicting whether muscle is truly hibernating or scarred.
We aim to evaluate a novel test called wave intensity analysis, where we assess the heart's blood flow during a diagnostic procedure called an angiogram. We would like to see if this test might be more accurate than those that are currently available at identifying these states of the heart muscle. This wave intensity analysis will be measured at rest and when the heart is stressed in a controlled manner, using intravenous medications.
We will ask people with heart failure who are due to have an angiogram if they want to take part in the study. Each participant will have a cardiac MRI scan and an echocardiogram performed at the start of the study. They will then have the wave intensity analysis test performed during their angiogram, followed by either stenting or surgery directed by their usual clinical care. This study will not change how the stenting or surgery is performed. They will then have another MRI scan 6 months later to see how well the heart recovered, and how well our test predicted this. This study will be conducted in hospitals that are centres of excellence in this type of cardiac research.
REC name
London - Chelsea Research Ethics Committee
REC reference
18/LO/0171
Date of REC Opinion
6 Mar 2018
REC opinion
Further Information Favourable Opinion