IMPULSE enhanced
Research type
Research Study
Full title
IMPULSE enhanced - Study to Improve Outcomes in Aortic Stenosis
IRAS ID
225305
Contact name
Peter Bramlage
Contact email
Sponsor organisation
IPPMed
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 10 months, 00 days
Research summary
Patients with severe aortic stenosis require urgent surgical or percutaneous intervention. Without timely treatment, prognosis is poor. Data from existing studies indicate that the treatment pathways for patients with severe aortic stenosis with or without symptoms are insufficiently defined. This lack of definition can contribute both to delay in treatment and inappropriate treatment decisions. While this has been confirmed in hospitals with a full complement of treatment modalities for this condition, including surgery and percutaneous options, it is not known whether a delay in treatment or the appropriateness of treatment decisions are better or worse in smaller hospitals without equivalent on-site access.
The aim of this multi-centre, prospective, observational cohort study is to outline the management of patients with severe aortic stenosis in participating centres with and without on-site access to surgery and percutaneous treatment. In combination with sites in Germany and France, patients from the identified site in the UK will be enrolled in the study if they have been diagnosed with severe aortic stenosis. The patients will be divided into two cohorts depending on the presence or absence of symptoms. Patients will be observed for the subsequent 12 months and the care that they receive, including any interventions, will be recorded. As this is an observational study, participation will not affect how the patients are treated.
The information collected in the study should improve the appropriateness and timeliness of treatment for patients with severe aortic stenosis.
REC name
West Midlands - Edgbaston Research Ethics Committee
REC reference
17/WM/0260
Date of REC Opinion
31 Aug 2017
REC opinion
Further Information Favourable Opinion