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Improving Outcome Measures For Adult CF ACT Trials

  • Research type

    Research Study

  • Full title

    Improving Outcome Measures For Physiotherapy Trials of Airway Clearance in Adults with Cystic Fibrosis



  • Contact name

    Gemma E Stanford

  • Contact email

  • Sponsor organisation

    Royal Brompton and Harefield NHS Foundation Trust

  • Identifier


  • Duration of Study in the UK

    4 years, 8 months, 0 days

  • Research summary

    Airway clearance techniques (ACTs) to clear sputum are key to cystic fibrosis (CF) management. There is no consensus as to which ACT is most effective as there is no accepted robust outcome to measure this. This research will compare historical outcome measures (sputum weight and FEV1) against new measures (electrical impedance tomography, lung clearance index, impulse oscillometry) investigating if there is a more scientific measure of ACT effect. This is essential to future scientific research into ACTs. CF patients will benefit from evidence that their daily physiotherapy regimes are effective, and NHS costs will be reduced by more effective regimes.

  • REC name

    London - Chelsea Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    27 Jun 2016

  • REC opinion

    Favourable Opinion