Improving Cognitive Recovery in Multiple Sclerosis
Research type
Research Study
Full title
CIRCuiTS MS: Improving Cognitive Recovery in Multiple Sclerosis
IRAS ID
348879
Contact name
Matteo Cella
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 5 months, 15 days
Research summary
This study aims to explore whether an adapted version of an existing cognitive rehabilitation programme (CIRCuiTS; https://www.circuitstherapyinfo.com) can be used to improve cognitive recovery for individuals with Multiple Sclerosis (MS). MS often affects cognitive abilities such as memory, attention, and problem-solving, which can impact daily life. Patients with MS have collaborated in workshops with the study's investigators to adapt the CIRCuiTS programme to better meet the needs of people with MS. Participants provided feedback on their cognitive difficulties and suggested changes to the programme’s content and delivery. This trial will assess the feasibility of delivering the adapted version and explore its potential benefits.
Twenty-four individuals with MS will participate in this pilot trial. Half will begin the adapted rehabilitation programme immediately, while the other half will receive treatment after a 13-week waiting period. The programme will consist of therapist-led and independent sessions of digitally-assisted cognitive rehabilitation tasks over a 12-week period. Feasibility will be assessed by analysing metrics such as adherence and retention, as well as qualitative data from participant exit interviews. The study will evaluate potential benefits by measuring improvements in goal attainment, cognitive performance, emotional well-being, fatigue, and daily living skills.
The findings from this research will inform the development of a protocol for a larger trial aimed at providing better cognition-focused treatments for people with MS. Ultimately, the goal of this project is to improve quality of life for individuals living with cognitive difficulties related to MS.
REC name
London - Brent Research Ethics Committee
REC reference
25/LO/0340
Date of REC Opinion
23 May 2025
REC opinion
Further Information Favourable Opinion