Improving adherence in nonadherent kidney transplant patients
Research type
Research Study
Full title
A pharmacist led, patient tailored intervention to improve immunosuppressant medication adherence in nonadherent kidney transplant patients
IRAS ID
232623
Contact name
Dawn Goodall
Contact email
Sponsor organisation
Joint Research Compliance Office, Imperial College London and Imperial College Healthcare NHS Trust
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Organs for transplantation remain a scarce and precious resource with over 5000 patients currently on the kidney transplant waiting list. A kidney transplant costs approximately £17,000 in the first year and £5,000 per subsequent year. If the transplant fails, the patient must return to dialysis at an estimated cost of £30,800 per year or be retransplanted. While short term outcomes have improved steadily over the last 15-20 years, longer term outcomes haven’t and after 10 years approximately 30% of kidney transplants have failed. Nonadherence to immunosuppressive medication is increasingly being associated with these poor long term outcomes and studies have estimated that 30-50% of transplant patients are nonadherent to their immunosuppressive medication. We want to determine whether immunosuppression medication adherence can be improved in a group of patients receiving tailored medication adherence support form a pharmacist. Adherence support will be provided for one year and will be individualised to each patient in the intervention group after identifying both their practical and perceptual barriers to adherence. The adherence interventions offered may include additional education and medication counselling, setting alarms, provision of a medication list, the use of a medications adherence app on a smart phone, reducing the number and frequency of tablets a patient takes or referral on to another health professional such as a social worker or psychologist for additional support. A range of clinical outcomes will be assessed for all patients on a regular basis in order to determine whether the provision of effective medication adherence support for our kidney transplant patients may help to optimise the long-term outcomes of these transplants.
REC name
London - Riverside Research Ethics Committee
REC reference
18/LO/0032
Date of REC Opinion
14 Jan 2018
REC opinion
Favourable Opinion