Improved diagnosis in patients with symptomatic bleeding disorders
Research type
Research Study
Full title
Improving diagnostic accuracy in patients with symptomatic bleeding disorders by the use of global tests of blood clotting.
IRAS ID
186735
Contact name
Stephen MacDonald
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and The University of Cambridge
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
Patients with unexplained excessive or spontaneous bleeding are frequently referred to the haemophilia centre at Addenbrooke's. This is a regional comprehensive care centre for bleeding disorders and the haemostasis laboratory is a specialised reference centre. At present we are able to characterise the nature of the bleeding tendency in patients referred to our centre in less than 30% of cases. In addition patients known to the centre often have symptoms that are not fully explained by current laboratory tests. This compromises our ability to reassure patients and plan treatment strategies to prevent or reduce bleeding. This high proportion of patients in whom we are unable to define the underlying problem is representative of the world-wide experience. In order to improve diagnostic accuracy we are continually improving the accuracy and precision of established clotting tests and developing more global tests of blood clotting capacity.This programme requires the use of patient samples both with and without known clotting defects, for assessment and validation of tests.
The purpose of this application is to obtain approval to store plasma from patients attending the haemophilia clinic. This will only be undertaken with patients written consent and for the sole purpose of improving diagnostic tests for use in patients investigated in the clinic with a personal or family history of bleeding.REC name
West of Scotland REC 3
REC reference
16/WS/0049
Date of REC Opinion
18 Feb 2016
REC opinion
Favourable Opinion