Implications of Physical Activity on CPET in a Prostate Cancer Sample
Research type
Research Study
Full title
Feasibility Randomised Controlled Trial to explore implications of a physical activity intervention on Cardiopulmonary Exercise Testing (CPET) and other outcomes in men with localised prostate cancer prior to radical prostatectomy
IRAS ID
232488
Contact name
Claire Perks
Contact email
Sponsor organisation
University of Bristol
ISRCTN Number
ISRCTN86024738
Duration of Study in the UK
1 years, 5 months, 30 days
Research summary
Implications of Physical Activity on CPET in a Prostate Cancer Sample is a two-arm randomised controlled feasibility study. Men with localised prostate cancer, who are due to undergo radical prostatectomy at Southmead Hospital, Bristol, will be randomised into a physical activity intervention arm, or control arm, 4-6 weeks prior to their surgery.
Men in the intervention arm will be asked to walk at a brisk pace for 30 minutes, on at least 5 days a week, on top of normal physical activity, with the additional aim to walk 10,000 steps every day. They will be given wrist worn physical activity monitors which will provide real time feedback and motivational messages. Participants will carry on with the intervention until their radical prostatectomy.
Men in the control arm will be asked to continue with their usual physical activity levels.
The study aims to explore the impact of moderate-vigorous physical activity on measures for fitness, in men with localised prostate cancer, as measured by CPET (Cardiopulmonary Exercise Testing). It will explore whether the intervention is associated with improved CPET measurements and alterations in metabolic markers in blood/tumour tissue.
Blood, tissue and CPET will take place at baseline and follow-up at the time of surgery. Tissue will be analysed to examine effects of the intervention on markers of cell proliferation and metabolic pathways. Blood will be analysed for change in biomarkers of prostate cancer: prostate specific antigen (PSA) level and insulin-like growth factor I (IGF-I)
Differences in fatigue and Quality of Life (QoL) prior to surgery will be assessed following the intervention.
Randomisation and retention rates will also be analysed.REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
17/EM/0446
Date of REC Opinion
31 Jan 2018
REC opinion
Further Information Favourable Opinion