IMPACT Study
Research type
Research Study
Full title
Intervening with a Manualised Package to AChieve treatment adherence in people with Tuberculosis: the IMPACT study
IRAS ID
231542
Contact name
Marc Lipman
Contact email
Sponsor organisation
University College London
ISRCTN Number
ISRCTN95243114
Clinicaltrials.gov Identifier
Z6364106/2018/05/135, UCL Data Protection Registration
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Compared to the rest of the UK and Western Europe, England has a major problem with the infectious disease tuberculosis (TB). The large amount of TB in the country has led Public Health England (PHE) and NHS England to develop a national TB control plan(1). Treatment lasts a long time (at least six months, and even more in people with drug resistant TB). Finding ways to make sure that people are able to take all of their prescribed medication is one of the plan’s priorities. If people miss doses (described as being ‘non-adherent or poorly adherent to treatment), their TB can develop resistance to the usual drugs, risking both their health and that of others.
At present we don’t have good ways of knowing if someone will struggle with their medication. In this study, we will use high quality research methods to find out why taking treatment may be difficult for some people, and how health services can work with them to improve this, or even avoid it happening.
Our proposal will:
1) Summarise current understanding of adherence to TB treatment
2) Work with social and behavioural scientists, doctors, nurses, people with TB and their carers to build on current understanding of personal, socio-cultural, and health systems mechanisms that can affect adherence to TB treatment in the NHS
3)develop a guide to help identify likely problems with adherence and pinpoint support options than can help people improve adherence to TB treatment according to their needs;
4) Testing out the guide with real patients in a small pilot study.
5)Evaluate how the guide was put into practice (what went well and what did not) from the point of view of patients and health professionals
6)Calculate the cost of introducing the guide across the NHS and design a definitive study to test whether the guide works as intended.REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
18/LO/1818
Date of REC Opinion
24 Dec 2018
REC opinion
Further Information Favourable Opinion