Impact of frailty on hospital outcomes in elderly patients.
Research type
Research Study
Full title
Impact of frailty on outcome prediction for elderly patients admitted to intensive care and the ward.
IRAS ID
247109
Contact name
Luke Hodgson
Contact email
Sponsor organisation
Western Sussex Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Frailty is a distinctive health state related to the ageing process in which multiple body systems gradually lose their in-built reserves and is one of the most-challenging consequences of population ageing. Although well established in the geriatric approach, it has only recently been studied in the intensive care unit (ICU), with little data from UK populations.
The clinical frailty score (CFS) a simple score on a scale of 1-9 based on severity of frailty and is widely used in the Trust where this study will be performed. It is electronically recorded at admission for all patients over 65 years of age. Coastal West Sussex today with 25% of the population over 65 closely resembles the projected demographic of England by 2035. We will perform a 1-year dual-centre observational study using a prospectively gathered large data-set (>18,000 hospital admissions) to address the following research questions:
1. What is the impact of frailty on outcome from both patients admitted to ICU and on the ward?
2. Can the CFS, when added to other electronically collected information help risk stratify patients (to highlight those at highest risk of poor outcomes)?
The studies main objectives are:
1. Describe the prevalence of frailty in the ICU and on the ward
2. Report mortality and relation to age and frailty score in ICU, in-hospital, and up to 1-year
3. Report discharge destination on follow-up - for example how many patients who survive ICU are admitted to institutional care.
4. Analyse the utility of the CFS as a predictor of adverse outcomes in addition to currently utilised observations (such as heart rate and blood pressure and alerts such as acute kidney injury (a sudden decline in kidney function).This study will provide important information for healthcare workers, patients and policymakers and help to guide future planning in the NHS.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
18/SC/0513
Date of REC Opinion
12 Oct 2018
REC opinion
Further Information Favourable Opinion