Impact of Artificial Feeding on Patient Reported Outcome Measures
Research type
Research Study
Full title
Impact of Nutritional Status and Dependence on Artificial Feeding on Patient Reported Outcomes in Adults Receiving Home Parenteral Nutrition
IRAS ID
201276
Contact name
Sorrel Burden
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
0 years, 8 months, 28 days
Research summary
Parenteral nutrition is also known as intravenous feeding and refers to the artificial tube method of providing nutrition to the body through the veins. \nIn 2010, the British Artificial Nutrition Survey reported that 624 adults needed home parenteral nutrition (HPN) in the UK (long term provision of HPN whilst at home). Drawbacks of long term HPN can be due to complications, which may reduce life expectancy. Complications could include: line blood stream infection; line and central venous clotting; metabolic bone disease and liver dysfunction. Predicting level of HPN need is difficult and there remains a lack of research on the impact of parenteral nutrition (PN) on patient reported outcome measures (PROMs). \n\nQuality of Life (QoL) has been shown to be steadily lower in those needing HPN compared to the general population. In addition, increased numbers of PN complications, PN size and PN rate, have all been associated with lower QoL. However, our recent review showed that there are no published data describing the impact of such patient factors on QoL, as measured using a HPN-specific PROM; furthermore, there are also no data outlining the impact of body composition on the HPN-specific PROM. \n\nThe proposed study aims to further assess the factors that impact PROMs in a future cohort of people needing HPN. This will be achieved by using a newly developed PROM tool (TONIQ) at Salford Royal Hospital along with a brief questionnaire, assessing factors such as demographics, PN size, PN rate, length of HPN, and causal disease.\n\nWe will also gauge the role of new methods (CT scans, ultrasound and BIA) to measure body composition in patients needing HPN; later, we will also determine if there is any impact of measured body composition on PROMs.\n
REC name
South West - Frenchay Research Ethics Committee
REC reference
16/SW/0146
Date of REC Opinion
25 May 2016
REC opinion
Further Information Favourable Opinion