IMPACT-CTO STUDY
Research type
Research Study
Full title
The physiological impact of coronary chronic total occlusion (CTO) percutaneous coronary intervention (PCI) on coronary pressure-derived measurements, its correlation in the donor vessel and the influence of collateral circulation.
IRAS ID
180174
Contact name
Thomas Keeble
Contact email
Sponsor organisation
Basildon & Thurrock University Hospital
Duration of Study in the UK
1 years, 6 months, 0 days
Research summary
Humans are generally born with 3 major coronary arteries (left, right and circumflex) supplying blood to the heart. During life arteries can become narrowed or blocked. We now have sophisticated techniques using wires and stents to unblock, or hold open narrowed / blocked arteries.
The decision to stent a narrowed artery is not straight forward, and can involve the need to assess the narrowing using a wire that can measure pressure to ensure that a stent will improve the flow. This is termed pressure wire assessment. Unfortunately pressure wire assessment is not validated in the presence of a blocked artery. For instance if the right artery is blocked, measurement of pressure / flow in the left artery can be misleading as the left artery is having to work harder supplying blood and oxygen to both the right and left territories through extra connections (collaterals) that the heart develops.
The purpose of IMPACT CTO is to better understand pressure wire readings from both blocked and narrowed arteries, to better guide treatment for our patients, as to whether they might be best treated with medications, stents or potentially bypass surgery.
This is a prospective analytical study. We aim to recruit 42 patients over an 18 month period, within the Essex Cardiothoracic Centre (CTC). Patients eligible will be those in whom their right heart artery is blocked and we are going to attempt stenting. Patients will undergo their standard artery unblocking procedure with stents, but will also have pressure assessments made in both the right and left heart arteries before and after the stenting.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
15/EE/0269
Date of REC Opinion
8 Sep 2015
REC opinion
Further Information Favourable Opinion