Impact & acceptability of 10 year risk at breast cancer screening v1
Research type
Research Study
Full title
Establishing feasibility of BC-Predict: effects on benefits, harms and healthcare use. Providing breast cancer risk information as part of the NHS Breast Screening Programme (NHS BSP): building an evidence base on benefits and harms to inform a decision to implement.
IRAS ID
248052
Contact name
David French
Contact email
Sponsor organisation
Manchester University NHS Foundation Trust
Duration of Study in the UK
1 years, 5 months, 30 days
Research summary
The National Institute for Health and Care Excellence (NICE) states that women at high-risk of breast cancer should have more frequent breast mammography (x-ray) screening and be offered risk-reducing treatment with the medicines tamoxifen, raloxifene or anastrozole. However women at increased risk of breast cancer in the NHS Breast Screening Programme (NHSBSP) cannot be offered prevention drugs or extra screening as the screening programme does not currently estimate or inform women of their risk.Breast Cancer (BC) Predict will automate the breast cancer risk estimation process so that it is feasible for roll-out in the wider NHSBSP.
The aim of this study is to test the effect of communicating personalised estimates of breast cancer risk (BC-Predict) on acceptability, informed choices and possible harms to women offered personalised risk estimates. This project will examine the benefits to service users of introducing BC-Predict as part of the NHSBSP, and identify the potential impact of BC-Predict on healthcare resource use and NHS workload.
A proportion of women invited to participate in the BC-Predict study and a proportion who received standard breast screening will be invited to participate in the questionnaire study. Those opting to participate will join via online consent, following which they will a questionnaire asking about anxiety, worry, risk, attitudes to screening, intentions, capability, health status, and healthcare resource use. Women will be asked to complete the questionnaire at two future time points (3 and 6 months post mammogram).
This project will also use individual interviews to explore how women feel about receiving their 10-year risk of developing breast cancer as part of the NHSBSP. We will also conduct focus groups with healthcare professionals to examine the perceived impact that providing 10-year risk of breast cancer to women in the NHSBSP has on the screening programme, General Practice, and Secondary Care (breast cancer Family History Clinics; FHCs).
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
18/NW/0856
Date of REC Opinion
25 Feb 2019
REC opinion
Further Information Favourable Opinion