iMODERN
Research type
Research Study
Full title
Instantaneous wave-free ratio guided multi-vessel revascularization during percutaneous coronary intervention for acute myocardial infarction
IRAS ID
239022
Contact name
Justin Davies
Contact email
Sponsor organisation
Radboudumc (Nijmegen)
Clinicaltrials.gov Identifier
Duration of Study in the UK
8 years, 8 months, 31 days
Research summary
Heart attacks (also called myocardial infarctions) are caused by blockages in coronary arteries (the blood vessels of the heart) which stops blood flow to part of the heart muscle. Patients who have experienced a heart attack and have been hospitalised will have a test called an emergency cardiac catheterisation to identify which artery is blocked. A small metal tube called a stent is used to open this blocked artery and allow blood to flow again. In addition to identifying the blocked artery, this test can also show whether other blood vessels in the heart have narrowings. The procedure to widen or unblock an artery is known as a percutaneous coronary intervention (PCI). At present most heart attack patients leave hospital without receiving treatment for these narrowings.
The purpose of this study is to investigate what is the best treatment for these narrowings following a heart attack. There are currently several options, but it is unclear which one is best. This study will compare two treatment options:
One option is to treat these narrowings at the same time as the blocked artery, during the emergency cardiac catheterisation procedure. To help doctors decide which narrowings need treatment and which can be left alone, fine wires are passed into the arteries and pressure measurements are made. These pressure measurements tell the doctor how severe the narrowing is. If the narrowing is significantly reducing blood flow then a stent will be used to widen the narrowing. If blood flow is not affected, then these narrowings need no additional treatment. This group will be known as the Immediate Additional PCI group.
Another option is to have an MRI-scan of your heart within 6 weeks after the heart attack. The MRI-scan will show whether the narrowings in the arteries are blocking blood flow to the heart muscle. If the narrowing does significantly reduce blood flow to the heart muscle then a stent will be used to widen the narrowing. If blood flow is not affected, then these narrowings need no additional treatment. This group will be known as the MRI-scan group.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
18/YH/0127
Date of REC Opinion
21 May 2018
REC opinion
Further Information Favourable Opinion