Immunological and microRNA profile in GBM - v.1.0
Research type
Research Study
Full title
Immunological and micro-RNA profile of glioblastoma multiforme patients - a pilot study
IRAS ID
201696
Contact name
Josephine Jung
Contact email
Sponsor organisation
King's College Hospital Foundation Trust
Duration of Study in the UK
0 years, 2 months, 1 days
Research summary
Despite advances in the treatment of patients with high grade gliomas, survival remains poor. Evidence shows that some patients react better than others to current treatment methods but the reason behind this is still unclear. Identifying patients that will respond better to specific treatment with a minimally invasive procedure is of paramount importance.
The immune system plays an integral role in the defense against malignant tumours. The relationship between the two and the use of immunotherapy has been better described in other types of solid tumours outside the central nervous system. There is now evidence showing that factors of the immune system change with treatment and that the immunological profile of patients is affected by substances released by tumours themselves.
In this study, we aim to create an immunological and microRNA profile in an attempt to identify peripheral markers that differ in patients with high grade gliomas compared to healthy controls and also compare the levels of those factors before and after surgery before proceeding to the formal study with which we will test how these markers change with treatment and whether they have any predictive value.
Eligible patients will undergo blood sampling twice. The first sample will be taken before the operation and will derive from the bloods drawn for the regular pre-operative preparation. The second sample will be taken 2 days after the operation, again with routine post operative check of the patients. This means that patients will have no more venous punctures than they would normally have during their hospital admission for the operation.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
16/EM/0201
Date of REC Opinion
11 May 2016
REC opinion
Further Information Favourable Opinion