Immunological and imaging features of spondyloarthritis
Research type
Research Study
Full title
Immunological and radiographic markers of disease activity in spondyloarthropathy and their response to treatment
IRAS ID
208355
Contact name
Coziana Ciurtin
Contact email
Sponsor organisation
UCL
Clinicaltrials.gov Identifier
Z6364106/2017/07/36 , Data Protection number
Duration of Study in the UK
14 years, 4 months, 1 days
Research summary
Spondyloarthritis (SpA) is a heterogenous group of diseases which share common clinical, radiographic and genetic features. It is one of the most frequent varieties of inflammatory rheumatic disorders with an estimated prevalence of 0.1-1% in Caucasians. SpA is characterised by the presence of inflammatory back pain, peripheral arthritis, enthesitis, uveitis and an association with human leucocyte antigen (HLA) B27.
Primary objective:
The overall aim of this project is to investigate the immunological and radiological features associated with active spondyloarthritis and to assess response to therapy.
Secondary objectives:
1. To correlate the immunological and imaging findings with clinical characteristics, including axial and peripheral disease manifestations, and disability scores.
2. To assess whether there are subgroups of patients characterized by their immunological and radiological profiles which have a different clinical course and response to treatment
3. To assess if there is any correlation between the clinical and laboratory parameters of disease activity with ultrasound of peripheral enthesitis sites and MRI examination of sacroiliac joints.
4. To analyse immune cell phenotype and functional profile in peripheral blood from patients with spondyloarthropathy compared to healthy donors, and correlate it with serological abnormalities, clinical and imaging features of the disease.
Tertiary objectives:
Clinical data will be used to create a comprehensive database that can be used to identify specific patient subgroups. This will provide long term benefits for further translational projects. The database will be overseen by Drs Leandro, Machado, Jones and Ciurtin with advice from the Biostatistical Group at the UCL/UCLH Joint research office.REC name
London - Riverside Research Ethics Committee
REC reference
18/LO/0216
Date of REC Opinion
28 Mar 2018
REC opinion
Further Information Favourable Opinion