Immunohistochemical Markers in Colorectal Cancer Assessment v1

• Research type

  Research Study

• Full title

  Analysis of the clinicopathological utility of immunohistochemical markers in diagnostic biopsies for colorectal cancer.

• IRAS ID

  125980

• Contact name

  Laila Hatsell

• Contact email

  Laila.Hatsell@mkhospital.nhs.uk

• Sponsor organisation

  Milton Keynes Hospital - NHS

• Research summary

  This study aims to determine whether an association between the immunohistochemical expression of three markers; P53, CD15 and CD10, can be used to predict the status of certain clinicopathological characteristics of colorectal tumours including lymph node metastasis, extramural vascular invasion and tumour stage. This will be performed retrospectively using the diagnostic biopsies. The clinicopathologic characteristics can be obtained from the histopathology reports of the resection. If an association is seen it will provide evidence for the use of immunohistochemical profiles in the pre-operative prognostic assessment of colorectal adenocarcinoma.

• REC name

  East of England - Cambridge Central Research Ethics Committee

• REC reference

  13/EE/0420

• Date of REC Opinion

  20 Dec 2013

• REC opinion

  Favourable Opinion