Immunohistochemical analysis of thyroid cancer tissue samples
Research type
Research Study
Full title
Characterisation and interaction of immune cells and oncological markers within the thyroid tumour microenvironment.
IRAS ID
179773
Contact name
John Greenman
Contact email
Sponsor organisation
Hull and East Yorkshire NHS R&D
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Thyroid cancer remains the most common malignant endocrine tumour. The incidence of Thyroid cancer in 2008 was 5.1 /100,000 for women and 1.9/100,00 in men. This is thought to be increasing worldwide. This study aims to examine the tumour microenvironment using immunohistochemical techniques to investigate the interactions between the immune cells and tumour cells. This will also allow the type of T cells involved in thyroid cancer to be characterised as well as determining the presence of other immunological/ oncological markers whose presence can be correlated with disease progression/stage and outcome. The data from this study will be compared with those obtained from the additional study (pending ethical approval) which involves looking at both tumour and peripheral(blood)T cells.
The results of both studies will help to clarify the current understanding of the role of immune cells in thyroid cancer, how these interact with the tumour and ultimately allowing appropriate targeted treatments for thyroid cancer.REC name
South West - Frenchay Research Ethics Committee
REC reference
15/SW/0241
Date of REC Opinion
26 Oct 2015
REC opinion
Further Information Favourable Opinion