Immuno-nutrition in haemodialysis
Research type
Research Study
Full title
Effect of immuno-nutrition on systemic inflammation in people receiving haemodialysis: a pilot study.
IRAS ID
309937
Contact name
Maarten W Taal
Contact email
Sponsor organisation
University of Nottingham
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
000, 000
Duration of Study in the UK
0 years, 2 months, 29 days
Research summary
The purpose of this study is to test if an “immuno-nutrition” supplement can decrease inflammation in people on haemodialysis. This immuno-nutrition supplement is high in calories and protein like other common nutritional supplements, but also contains a unique combination of ingredients that have been shown to reduce inflammation (a problem which is caused by the body’s defence [immune] system communicating that something is wrong) and improve the immune system in people with cancer. We hope that this small study will help us gain a good understanding of the effect of immuno-nutrition on inflammation in people on haemodialysis, which will guide and allow us to do a larger research study in the future.
Participants will be asked to take one sachet of the immuno-nutrition supplement each day for 6 weeks. The renal dietitian on the research team will provide participants with detailed oral and written advice on how and when to take the immuno-nutrition supplement and how to keep to your diet.
Participants will need to complete 3-day food diaries at the beginning, mid-way point and end of the study.
The research team will measure weight, height, handgrip strength (a measure of muscle strength), body’s composition of fat and muscle using a specialist scale, and skin autofluorescence levels (a measure of toxins called advanced glycation end-products). The research team will collect the results of routine blood tests. The research team will also collect and store blood samples taken before and after a haemodialysis session to measure some molecules that indicate inflammation.
All of these measurements and samples will be taken at the start of the study, and after 6 weeks of taking the immuno-nutrition supplement.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
22/EM/0026
Date of REC Opinion
2 Mar 2022
REC opinion
Further Information Favourable Opinion