Immunity and Infection Research Tissue Bank (IIRTB)
Research type
Research Tissue Bank
IRAS ID
149791
Contact name
Adam Finn
Contact email
Research summary
Immunity and Infection Research Tissue Bank (IIRTB)
REC name
South West - Central Bristol Research Ethics Committee
REC reference
08/H0106/132 + 5
Date of REC Opinion
4 Apr 2014
REC opinion
Favourable Opinion
Data collection arrangements
A wide range of samples from adults and children may be deposited in the IIRTB, for example:
- pieces of tissue (e.g. adenoids, tonsils etc),
- fluids, secretions & swabs (e.g. blood, urine, stool, pus, saliva, nasal swabs etc)
- samples derived from processing other samples (e.g. cells extracted from blood etc)Samples may be obtained from:
- individuals receiving medical care
- pregnant women (umbilical cord & cord blood)
- healthy volunteers (mostly samples that are less invasive to collect, e.g. urine, saliva, nasopharyngeal swabs).
- clinical trials/research projects: samples collected for and left over at the end of clinical trials or other research projects may be deposited in the IIRTB, provided that consent for storage and future use in research within the remit of the bank has been obtained.After being identified, potential donors (and/or their parent/guardian) will be provided with a participant information sheet, and a member of staff will explain the purpose of the tissue bank and what is involved in becoming a donor. They will be given the chance to ask any questions they may have regarding the donation, before being asked to sign a consent form.
Research programme
Tissue within the bank will be used for research aiming to increase our understanding of the immune system, the immune response to infection and vaccination, and the nature of the interactions occurring between host and pathogen. Understanding such fundamental issues is critical for the generation of further effective vaccines as well as for the development of novel strategies for the diagnosis, prevention and treatment of infection and of other problems with the immune system. Particular emphasis and priority will be placed on research which aims to understand the nature of the host pathogen interaction with organisms such as pneumococcus and meningococcus, which colonise the upper respiratory tract. However, research addressing other questions relating to the immune response to infection and vaccination and to other aspects of the immune response and immune function, regulation and dysregulation will also fall within the remit of the bank. Projects addressing such questions could include basic, translational, and clinical research. Purely commercial research, which would not be expected to result in publication in peer reviewed journals, will not be undertaken using tissue from the bank.
RTBTitle
Immunity and Infection Research Tissue Bank (IIRTB)
Establishment organisation address
Senate House, University of Bristol
Tyndall Avenue
Clifton
BS8 1TH